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Rodents do not naturally menstruate, the only exception to date being the spiny mouse (10). Currently, there are few established captive colonies of spiny mice across the world, with various species used to study different aspects of biology.
The rodent estrous cycle repeats with a constant period of 4 to 5 days and includes the following phases: proestrus, estrus, metestrus, and diestrus1, 2, 5,6,7. Both ovaries exhibit the same morphological changes throughout the cycle and ovulate—bilaterally—at the same time.
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